Singh, S, Almuhanna, Y, Alshahrani, MY, Lowman, D, Rice, PJ, Gell, C, Ma, Z, Graves, B, Jackson, D, Lee, K, Juarez, R, Koranteng, J, Muntaka, S, Mitchell, D, da Silva, AC, Hussain, F, Yilma, G, Mastrotto, F, Irie, Y, Williams, P, Williams, D, Camara, M, Martinez-Pomares, L, Carbohydrates from Pseudomonas aeruginosabiofilms interact with immune C-type lectins and interfere with their receptor function, npjBiofilms and Microbiomes, 7, 87 (2021). https://doi.org/10.1038/s41522-021-00257-w
Douglas W. Lowman, Sameer Al-Abdul-Wahid, Zuchao Ma, Michael D. Kruppa, David L. Williams. Glucan and glycogen exist as a covalently linked macromolecular complex in the cell wall of Candida albicans and other Candida species. The Cell Surface, 7, 10061 (2021); doi: https://doi.org/10.1016/j.tcsw.2021.100061
Horton, M, Johnson, C, Zarnowski, R, Andes, B, Schoen, T, Kernien, J, Lowman, D, Kruppa, M, Ma, Z, Williams, D, Huttenlocher, A, Nett, J, Candida auris cell wall mannosylation contributes to neutrophil evasion through pathways divergent from Candida albicans and Candida glabrata. mSphere, accepted, 2021
Mariolina Bruno, Simone Kersten, Judith M. Bain, Martin Jaeger, Diletta Rosati, Michael D. Kruppa, Douglas W. Lowman, Peter J. Rice, Bridget Graves, Zuchao Ma, Y. Ning Jiao, Anuradha Chowdhary, George Renieris, Frank L. van de Veerdonk, Bart-Jan Kullberg, Evangelos, J. Giamarellos-Bourboulis, Alexander Hoischen, Neil A. R. Gow, Alistair J. P. Brown, Jacques F. Meis, David L. Williams, Mihai G. Netea, Transcriptional and functional insights into the host immune response against the emerging fungal pathogen Candida auris. Nature Microbiology, August 24 (2020) 1-16, https://doi.org/10.1038/s41564-020-0780-3
Matthew S. Graus, Michael J. Wester, Douglas W. Lowman, David L. Williams, Michael D. Kruppa, Carmen M. Martinez, Jesse M. Young, Harry C. Pappas, Keith A. Lidke, Aaron K. Neumann, Mannan molecular sub-structures control nanoscale glucan exposure in Candida. Cell Reports 24, 2432-2442, 2018.
·Smith, A.J., Graves, B., Child, R., Rice, P.J., Ma, Z., Lowman, D.W., Ensley, H.E., Ryter, K.T., Evans, J.T., Williams, D.L. Immunoregulatory activity of the natural product laminarin varies widely as a result of its physical properties. J. Immunol. 200(2):788-799, 2018.
She, X., Calderone, R., Kruppa, M., Lowman, D., Williams, D., Zhang, L., Gao, Y., Khamooshi, K., Liu, A., Li, D. Cell Wall N-Linked Mannoprotein Biosynthesis Requires Goa1p, a Putative Regulator of Mitochondrial Complex I in Candida albicans. PLoS ONE 11(1): e0147175. doi:10.1371/journal.pone.0147175, 2016.
Wilson, W., Lowman, D., Antony, S.P., Puthumana, J., Singh, I.S.B., Philip, R. Immune gene expression profile of Penaeus monodon in response to marine yeast glucan application and white spot syndrome virus challenge. Fish & Shellfish Immunology 43:346-356, 2015.
Lowman, D. W., Greene, R. R., Bearden, D. W., Kruppa, M., Pottier, M., Monteiro, M., Soldatov, D., Ensley, H. E., Cheng, S.-C., Netea, M. G., Williams, D. L. Novel Structural features in Candida albicans hyphal glucan provide a basis for differential innate immune recognition of hyphae versus yeast. J. Biol Chem 289 (6) 3432-43, 2014.
Williams, D.L., Lowman, D.W., Reale, M., Ensley, H.E. Insights into the physicochemical characterization, chemistry, structure and synthesis of (1→3,1→6)-b-glucans. Eds. V. Vetvicka and M. Novak, In: Biology and Chemistry of Beta Glucans, Vol. 2, p. 29-82, 2013.
West, Lara, Lowman, Douglas W., Mora-Montes, Hector M., Grubb, Sarah, Murdoch, Craig, Thornhill, Martin H., Gow, Neil A. R., Williams, David, and Haynes, Ken, “Differential virulence of Candida glabrata glycosylation mutants,” Journal of Biological Chemistry, 288(30), 22006-18, 2013.
Hall, R.A., Bates, S., Lenardon, M.D., MacCallum, D.M., Lowman, D.W., Kruppa, M.D., Williams, D.L., Odds, F.C., Brown, A.J.P, Gow, N.A.R. The Mnn2 mannosyltransferase family regulates mannoprotein fibril length, immune recognition and virulence of Candida albicans. PLoS Pathogens 9(4):e1003276, 2013.
“New Insights into the Structure of (1-3,1-6)-b-D-Glucan Side Chains in the Candida glabrata Cell Wall,” Douglas W. Lowman, Lara J. West, Daniel W. Bearden, Michael F. Wempe, Trevor D. Power, Harry E. Ensley, Ken Haynes, David L. Williams, Michael D. Kruppa, PloS ONE, 6(11): e27614 (2011)
“Mannan structural complexity is decreased when Candida albicans is cultivated in blood or serum at physiological temperature,” Douglas W. Lowman, Harry E. Ensley, Rachel R. Greene, Kevin J. Knagge, David L. Williams, Michael D. Kruppa, Carbohydrate Research 2011, 346, 2752-2759
“C. albicans increases cell wall mannoprotein, but not mannan, in response to blood, serum and cultivation at physiological temperature,” Michael Kruppa, Rachel R. Greene, Ilka Noss, Douglas W. Lowman, David L. Williams, Glycobiology 2011, 21(9), 1173-1180
“Marine yeast glucans confer better protection than that of baker’s yeast in Penaeus monodon against white spot syndrome virus infection,” V. Sukumaran, D. W. Lowman, T. P. Sajeevan, R. Philip, Aquaculture Research, 2010, 1-7
“Identification of (1-6)-b-D-glucan as the major carbohydrate component of the Malasezzia sympodialis cell wall,” Michael D. Kruppa, Douglas W. Lowman, Yu-Han Chen, Christine Selander, Annika Scheynius, Mario Monteiro and David L. Williams, Carbohydrate Research, 344, 2474-2479 (2009)
“The Candida albicans histidine kinase Chk1p: signaling and cell wall mannan,” Dongmei Li, David Williams, Douglas Lowman, Mario A. Monteiro, Xuan Tan, Michael Kruppa, William Fonzi, Elvira Roman, Jesus Pla and Richard Calderone, Fungal Genetics and Biology, 46, 731-741 (2009)
“Marine yeast diet confers better protection than its cell wall component (1-3)-b-D-glucan as an immunostimulant in Fenneropenaeus indicus,” T. P. Sajeevan, D. W. Lowman, D. L. Williams, Subramanian Selven, Abdulaziz Anas and R. Philip, Aquaculture Research, 40(16), 1799-1804 (2009)
“Alkali insoluble glucan extracted from Acremonium diospyri, is a more potent immunostimulant in the Indian White Shrimp, Fenneropenaeus indicus, than alkali soluble glucan,” Abdulaziz Anas, D. W. Lowman, D. L. Williams, S. Millen, S. Somnath Pai, T. P. Sajeevan, R. Philip and I. S. B. Singh, Aquaculture Research, 40(11), 1320-1327 (2009)
"Dendritic Cell Interactions with Candida albicans Critically Depends on N-Linked Mannan," A. Cambi, M. G. Netea, H. M. Mora-Montes, N. A. Gow, S. V. Hato, D. W. Lowman, B.-J. Kullberg, D. L. Williams, C. G. Figdor, Journal of Biological Chemistry, 283, 20590-20599 (2008)
“Differential high affinity interaction of Dectin-1 with natural or synthetic glucans is dependent upon primary structure and is influenced by polymer chain length and side chain branching,” Elizabeth L. Adams, Peter J. Rice, Bridget Graves, Harry E. Ensley, Hai Yu, Gordon D. Brown, Siamon Gordon, Mario A. Monteiro, Erzebet Papp-Szabo, Douglas W. Lowman, Trevor D. Power, Michael F. Wempe and David L. Williams, Journal of Pharmacology and Experimental Therapeutics, 325, 115-123 (2008)
“Introduction to the Chemistry and Immunobiology of Beta-Glucans,” David L. Williams, Douglas W. Lowman and Harry E. Ensley, Chapter 1 in “Toxicology of Glucans,” CRC Press, pg. 1-34 (2005)
"Structural characterization of (1®3)-b-D-glucans isolated from blastospore and hyphal forms of Candida albicans," Douglas W. Lowman, Donald A. Ferguson, and David L. Williams, Carbohydrate Research, 338, 1491-96 (2003)
"The role of the Candida albicans histidine kinase [CHK1] gene in the regulation of cell wall mannan and glucan biosynthesis," Kruppa, M., Goins, T., Cutler, J. E., Lowman, D., Williams, D., Chauhan, N., Menon, V., Singh, P., Li, D., and Calderone, R., FEMS Yeast Research, 3, 289-99 (2003)
"A Proton Nuclear Magnetic Resonance Method for the Quantitative Analysis on a Dry Weight Basis of (1®3)-b-D-Glucans in a Complex, Solvent-Wet Matrix," Douglas W. Lowman and David L. Williams, Journal of Agricultural and Food Chemistry, 49(9), 4188-91 (2001)
“A (1®3)-b-D-linked Heptasaccharide is the Smallest Unit Ligand Which Binds to Human Monocyte Glucan Receptors,” Elizabeth Lowe, Peter Rice, Tuanzhu Ha, Chuanfu Li, Jim Kelley, Harry Ensley, Jose Lopez-Perez, John Kalbfleisch, Douglas Lowman, Peter Margl, William Browder, and David Williams, Microbes and Infection, 3, 1-9 (2001)
“Identification of Phosphate Substitution Sites by NMR in a Water-Insoluble Phosphorylated (1®3)-b-D-Glucan Isolated from Saccharomyces cerevisiae,” Douglas Lowman, Harry Ensley and David Williams, Carbohyd. Res., 306(4), 559-62 (1998)
“The Application of Various Protic Acids in the Extraction of (1®3)-b-D-Glucan from Saccharomyces cerevisiae,” A. Muller, H. Ensley, H. Pretus, R. McNamee, E. Jones, E. McLaughlin, W. Chandley, W. Browder, D. Lowman and D. Williams, Carbohyd. Res., 299(3), 203-8 (1997
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